The ISO Clip provides a thermally broken and intermittent structural attachment for cladding systems to exterior wall assemblies. The clip is fabricated from Z-275 galvanized steel, and over-molded with a plastic isolator. Both horizontal and vertical steel girts can be attached to the ISO Clip, as shown below in Figures 1 & 2. The horizontal flange of the clip has a punched slot that allows the sub-girt to be adjusted and fastened to the clip. The plastic isolator between the metal clip and the wall provides a thermal break that reduces thermal bridging. For steel stud assemblies, the clips are fastened through the exterior sheathing directly to the steel studs using self-drilling screws.